Courage's mysterious past comes to light, when his parents were sent to space by a veterinarian. When Muriel and Eustace notice he is not responding, still haunted by that treacherous event, they take him to the same vet that sent his parents into space, unaware that the vet is now going to send the first humans to the moon, which will be Muriel and Eustace. Courage must save them after realizing that Muriel has become a major character in his life, besides his parents.
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Courage is a timid pink dog with paranoia problems. He and his owners live on a farm in the middle of Nowhere... literally. Despite being far away from everything and everyone, that doesn't stop a whole bunch of bizarre adversaries turning up like living nightmares. Courage must overcome his fear and help save his owners, Eustace and Muriel, from ghosts and paranormal spirits living on the farm. Although Muriel loves Courage, Eustace loves to tease him and scare him.